Acute Exposure of Endosulfan on Behaviour of Rats

Hypothalamus may also participate in the control of appetite as the lateral nuclei serve as the feeding centre which when stimulated causes hyperphagia . The destruction of lateral hypothalamus causes lack of appetite and progressive inanition, this is a condition characterized by loss of weight, decreased metabolism and muscle weakness Organochlorine pesticides are environmental contaminants because they break down very slowly. Albino rats of 4, 5 and 6 weeks of age were taken as experimental animal and acute sub lethal dose (0.31ppm/kg-1 bw, 0.32ppm/kg-1 bw and 0.34ppm/kg-1 bw, was injected to albino rats. Body weight, food consumption and water intake of animals were measured during 1 to 45 days. Results indicated that sub lethal dose of endosulfan affect food consumption, body weight and water intake. During 1 to 15 days these parameters were decrease in all the experimental rat and after 24th  to 27th days these parameter were recovered but four and five week of rats showed slow recovery in body weight, food consumption and water intake in comparison to 6 six week of rats. Hence in the present study the regular intervals of day 15th, day30th and day45th were selected to carryout studies relating to detoxification mechanism.