Article Subject

The present work reports a new spectrophotometric method for chlorpromazine hydrochloride
(CPZ) assay. This is based on the oxidative coupling ability of 3-Methylbenzthiazolinone-2-hydrzone
(MBTH) with the drug in presence of FeCl3 under acidic condition. The resultant water soluble colored
chromogen showed maximum absorbance at 720nm.The reaction system obeyed Beer’s law in the range
of 2-10μg/ml. The proposed method has been successfully applied for routine pharmaceutical analysis
of the sited drug.

Chlorpromazine hydrochloride
3 -Methylbenzthiazolinone-2-hydrzone
Beer’s law..
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