Cyclophosphamide (CP), [2-(bis-/2-chloro-ethyl-amino)-tetrahydro-2H-1, 2, 3 oxazaphosphorine-2-oxide], is an alkylating chemotherapeutic agent, which is commonly used against malignancies, such as leukemia, lymphoma, breast, lung, prostrate, and ovarian cancer. The aim of this study is to evaluate the side effect of CP on male albino rat in response to certain hepatic and renal enzymological parameters. In this investigation, total 20 albino rats were divided in to two groups of ten each. Group first served as control received i.p. injection of 0.9 physiological saline fed with standard food and water ad libitum. While, Group second received a single dose (0.2ml/100g b/w) through i.p. injection of cyclophosphamide once in a week for a period of one and five weeks and enzymological parameters i.e. glutamate oxyaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), acid phosphatase (ACP) and. alkaline phosphatase (ALP) levels in liver and kidney were quantified after 7 and 35 days of the treatments. The enzymological parameters i.e. GOT, GPT, ACP and. ALP levels in liver and kidneys were significantly increased after 7 and 35 days treatment of cyclophosphamide. The increased of these values was more prominent in later part of the experiment. Elevation in enzymological parameters after cyclophosphamide exposure may impaires the functional activities of liver and kidney of male Rattus norvegicus.
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