Issue
2011 volume.1
Article Category
Research Article
Article Subject
Biotechnology
Article Authors
B. Hari Babu
K. Bala Murali Krishna
P. Rama Krishnaveni
Abstract

A new simple, precise and accurate Reverse Phase High Performance Liquid Chromatographic (RPHPLC)
method for the estimation of Lapatinib in bulk drugs and pharmaceutical dosage formulations
was developed and validated. The method was developed by using the solvent system methanol,
potassium dihydrogen phosphate, and tetrahydrofuran in the ratio of 60:35:5 (v/v/v) at pH 6.2 was
given high resolution chromatogram with low tailing factor (<2). The method was successfully applied
for routine analysis of Lapatinib in bulk samples and its formulations.

Keywords
Lapatinib
estimation
RP-HPLC
Validation.
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