The Diseases Associated with a High Alp Level among Jordanian Adult Hospitalized Patients

Objective-Alkaline phosphatase (ALP) is an important enzyme mainly derived from the liver, bones and in lesser amounts from intestines, placenta, kidneys and leukocytes. An increase in (ALP) levels in the serum is frequently associated with a variety of diseases. This study was done in order to determine the diseases associated with a high (ALP) level among Jordanian adult hospitalized patients.
Method-A review was made of medical records of inpatients with high (ALP) level above 1000 IU/L in king Hussein Medical Center. Excluded were cases of (a) patients who have bone involvements with malignancies, (b) pediatric patients younger than 15 years old.
Results-A total of 180 hospitalized patients with eligible medical records were identified (97 males and 84 females, mean age 48.4 + 7.1 years). Their (ALP) levels ranging from 1,001 to 3,067 IU/L, these patients were divided into three groups.
Conclusion-High serum (ALP) levels in hospitalized patients were commonly found in three major group having obstructive biliary diseases, infiltrative liver disease and sepsis . The study results were in accordance with previous reports in developed countries