Diabetes mellitus as an endocrine disorder has over the years been treated with orthodox medicine and this have many drawbacks including undesirable side effects and high cost of long term treatment hence ethno botanicals have provided greater advantage over the earlier. The aim of this study is to determine the effect of ethanol extract and its fractions on biochemical parameters such as total protein, urea, Creatinine, AST and ALT levels of alloxan induced diabetic albino wistar rats. The respective extract and fractions at doses of 100 and 250 mg/kg were carried out using their sera. There were significant reductions (p < 0.05) in urea levels in groups treated with methanol fractions. All the fractions significantly reduced (p < 0.05) creatinine levels in the diabetic rats as compared with the diabetic control group. AST and ALT levels were significantly reduced (p < 0.05) in the groups treated with glibenclamide as well as methanol and butanol fractions. Analysis further showed slight increases in total protein levels in groups treated with dose dependent (100mg/kg) methanol and ethyl acetate fractions, ethanol extract (250 mg/kg) as well as n-hexane fractions. Hence butanol and methanol fractions of this plants exhibited some nephroprotective and hepatoprotective properties.
Abstract
Article PDF
PDF (For Download)