Issue
Article Subject
Chemistry
Abstract

A trihydroxy anthraquinone component from Cassia fistula fruit pulp belonging to
Legumenosae family was isolated from the toluene extract of fruit pulp by the process of
hot extraction and characterized as 1,3,8–trihydroxyanthraquinone (AQ) using various
spectroscopic techniques like I.R, U.V, NMR,and Mass. It is the first report of the
presence of 1,3,8 – trihydroxyanthraquinone in Cassia Fistula fruit pulp. In vitro
antioxidant activity of the compound was studied by superoxide and hydroxide radical
scavenging assay. This phytoligand was also subjected to in silico molecular docking
studies with CK2, P53 and ERK protein using iGEMDOCK software to investigate their
cytotoxic activity. The in vitro cytotoxic activity of this compound was then studied to
substantiate the data obtained from the docking studies in HT-29, DLA and A375 cell
lines. Its Chorio Allantoic Membrane (CAM) assay was also performed in chick embryo to
find the antiangeogenic activity
 

Keywords
Cassia fistula
Fruit pulp
1
3
8–trihydroxyanthraquinone
iGEMDOCK
Antioxidant
HT–29
DLA
A375
antiangeogenic
CAM. 1. Introd
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