Measurement of Creatine Kinase and Creatine Kinase – Mb Isoenzyme in Myocardial Infarction Patients

Objective -this study has been carried out to determine the significance of measurement of total CK and Ck –MB in the diagnosis of acute myocardial infarction.
Method -We evaluated diagnosis strategy by studding 800 patients aged 30-70 ( with control group). Suspected of having had an acute myocardial infarction. investigation were carried at king Hussein Medical Center ( Queen Alia Heart Center)
Serum total CK and CK-MB was done by CK,CK –MB NAC activated methods using Hitachi autoanlyzer.
Results -In AMI patients,the mean value of total Ck is greater than that of the normal range . Also the mean value of Ck – MB and % CK– MB is greater than that of normal range in both sexes . The maximum peak was found to be 8 hours for males and females . After the onset of myocardial infarction.
Conclusion -This study demonstrated that measurement of total CK and CK- MB is currently the test of choice to confirm the diagnosis of an AMI . Measurment of total CK and CK-MB every 8 – 12 hours is an adequate coast – effective method for the diagnosis of AMI It was found that total CK and CK – MB is an effective way of identifying people at high risk of AMI .