The present study is centered on the concept that Macrosomia is a frequent complication of pregnancy in diabetes mellitus.
In this article, we shed light on the abnormalities in lipoprotein fractions in Diabetic pregnancy can act as a measure of macrosomia. We also raise the question of the possible
beneficial effects of n-3 PUFAs in diabetic pregnancy in the prevention and treatment of
long-term metabolic abnormalities associated with macrosomia.
The cases for this study were selected from the Gynaecology and Obstetrics 'Out-patients' and 'In-patients' clinic of Sassoon General Hospital,Pune. In all 130 cases belonging to the age group of 20-45 years could be studied. Out of the 130 subjects, 50 subjects belonging to the III trimester of pregnancy were studied. The study could evaluate 30 subjects belonging to the III trimester diabetic pregnancy group. 50 healthy non-pregnant women constituted the control group
Ill trimester diabetic pregnant women exhibited elevated levels of Malondialdehyde levels (MDA) as compared to III trimester normal pregnant women.
Lipid peroxides in lipoprotein fractions i.e. HDL, LDL, VLDL exhibited a significant increase in diabetic pregnant women as compared to normal III trimester pregnant women.Free fatty acid levels were significantly increased in III trimester diabetic pregnant women as compared to III trimester normal pregnant women.