Issue
Article Subject
Pharmacy
Abstract

This study was carried out to investigate the free radical scavenging potential and hepatoprotective activity of the ethanolic and aqueous extract of the Actiniopteris dichotoma using paracetamol, Diclofenac and CCl4 hepatotoxicants. Extracts were used for estimation of radical scavenging potential of the plant. Plant extracts at the dose of 250 and 500 mg/kg, p.o. and silymarin as a standard drug were administered in intoxicated rats and hepatoprotective potential assessed by different biochemical parameters like AST, ALT, ALP, total protein, bilirubin, and albumin content by UV kinetic assay. At the dose of 250mg/kg, p. o. offered significant (P<0.05) but dose 500mg/kg, p. o. offered significant (P<0.01) compared with that of standard silymarin (P<0.001). Ethanolic and aqueous extract of the Actiniopteris dichotoma bedd showed hepatoprotective effect against paracetamol, diclofenac and CCl4- induced hepatotoxicity, which was evidenced by the significant decrease in ALT, AST and ALP. On the light of the present study it is concluded that the ethanolic and aqueous extract of the selected plant could protect liver against oxidative damages and could be used as an effective protector against hepatotoxicants induced hepatic damages.

Keywords
Antioxidant
Hepatoprotective
Actiniopteris dichotoma bedd
Diclofenac
CCl4 Paracetamol
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