This paper reports that the rational design of N-1 and C-7 substituted fluoroquinolones derivatives, after
synthesis and biological evaluation against gram negative and gram positive bacteria and this class of drug is
DNA gyrase and growth inhibition activity. Fluoroquinolones are one of the most promising and vigorously
pursued areas of contemporary anti-infective chemotherapy depicting broad spectrum and potent activity. They
have a relatively simple molecular nucleus, which is amenable to many structural modifications. These agents
have several favorable properties such as excellent bioavailability, good tissue penetrability and a relatively low
incidence of adverse and toxic effects. They have been found effective in treatment of various infectious diseases.
This paper is an attempt to review the therapeutic prospects of fluoroquinolones antibacterial with an updated
account on their development and usage.
Abstract