Abstract
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated
for rapid assay of Quetiapine in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was
employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of
Methanol:Acetonitrile:OPA 35:35:30 (v/v/v). The UV detection wavelength was at 238nm.Linearity was
observed in concentration range of 10-35ppm. The retention time for Quetiapine was 7.33 min. The
method was validated as per the ICH guidelines. The proposed method can be successfully applied for
the estimation of Quetiapine in pharmaceutical dosage forms
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