Abstract
A Simple, precise and accurate RP-HPLC method was developed and validated of clobazam in pharmaceutical dosage forms. Isocratic elution at a flow rate of 1ml min-1 was employed on a chromosil C18 column (250 mm x 4.6 mm, 5μ) at ambient temperature. The mobile phase consisted of Water: Methanol: Acetonitrile in the ratio of 55:25:20 (v/v/v). The UV detection wavelength was at 231nm. The retention time for clobazam was found to be 4.49min. Linearity was observed in the concentration range of 10-40ppm. The method was validated as per ICH guidelines
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