Solid State Compatibility Studies between Ranolzine with Some Excipients By Using HPLC & FTIR

Compatibility studies are essential for preformulation studies of formulation development. In the present study, the possible interactions between Ranolzine and some excipients (HypermelloseHP55, Ethocol7FP premium, Natrasoltype 250HHX, Klucel HF pharma, Avicel PH 101) were evaluated by examining the pure drug or drug-excipient powder mixtures which were stored under different conditions (40°C/75%RH after 28 days) using, Fourier Transorform Infrared Spectroscopy(FTIR) and High Performance Liquid Chromatography(HPLC). The results demonstrate the suitability of Ranolazine with HypermelloseHP55, Ethocol7FP premium, Natrasoltype 250 HHX, Klucel HF pharma, Avicel PH 101.