Synthesis and Anti-Tubercular Activity of 8- Bromo-4-Chloro Benzofuro[3,2-D] Pyrimidines

3-amino-5-bromo-1-benzofuran-2-carboxamide (3) was prepared by the reaction of 5-
bromosalicylonitrile (2) with chloroacetamide in dry acetone in presence of anhydrous
potassium carbonate to maintain basic condition. The claisen-schmidt condensation
of compound (3) with various substituted aromatic aldehydes in presence of strong
acid in absolute ethanol underwent cyclization and resulted in the formation of 8-
bromo-2(phenyl substituted)benzofuro[3,2-d]pyrimidin-4(3H)-ones (4a-e) in good
yields. The compounds (4a-e) upon treatment with phosphorus oxychloride to gave
above titled compounds (5a-e). All synthesized compounds were characterised on the
basis of IR, 1H-NMR, mass spectra, physical and analytical studies. Further these
compounds were evaluated for their antibacterial, antifungal and anti-tubercular
activities.