Synthesis and Antimicrobial Activity of 4-Substituted-5,6,7,8-Tetrahydro[1] Benzothieno[2,3-D] Pyrimidines (Stbp) Under Comparative Methods

Two convenient methods for synthesis of 4-substituted-5,6,7,8-tetrahydro[1] benzotheino [2,3-d] pyrimidines derivatives (4a-f) were prepared by the displacement reaction between various amines and 4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d] pyrimidine (3). The relative advantage of greener pathway, which use MW, irradiation and eco-friendly aqueous reaction method, for the synthesis of various heterocyclic compounds. All the synthesized compounds have been carried out under conventional and microwave irradiation methods.