Toxicity Study of Two Transition Metal Complexes in Swiss Albino Mice

Two schiff base complexes namely N-salicylideneglycinato-aqua-copper (II), (SGC) and N- salicylideneglycinato- di-aqua-nickel (II) dimer, (SGN)2 were used to study hematological and biochemical parameters in swiss albino mice. Acute toxicity of (SGC) and (SGN)2 were studied by evaluating median lethal dose LD50. Hematological parameters i.e. RBC, WBC, Hb content and some biochemical parameters i.e. urea, glucose, protein, cholesterol, AST, ALT, ALP were determined by standard methods. The test compounds much below the LD50 values modestly altered hematological and biochemical parameters from normal values but restored gradually almost towards normal after the treatment periods. Both (SGC) and (SGN)2 can be used as therapeutic agents.