Nephroprotective and Hepatoprotective Activity of Cold Pressed Extract of Nigella Sativa L Oil in Rat

Posted by ijrrpas | Posted in IJRRPAS (2017) VOL.7(1) | Posted on 05-12-2017

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Authors:
Rawoof khan.G, Saeed Ahmed khan

Abstract:
Herbal medicines are use of herbs for their therapeutic (or) medicinal values for its medicinal. Nigella
sativa Linn. is family of Ranuculaceae, commonly known as the black cumin seed. N. sativa seeds oil
were used for the extraction of their oil by way of cold press method using the machine and filter to
determine the physicochemical properties. Eight groups were employed in the present study and four
groups for nephrotoxicity and four groups heptotoxicity comprised six rodent rats. Nephrotoxicity
induce by Gentamicin (80 mg/kg/day) intraperitonially was administered for 10 days in rats for four
groups. Heptotoxicity induced by 1g/kg of paracetamol for four groups of animals after fasting. After 28
days treatment, all groups are anesthetized and blood was collected by retro orbital puncture and
serum was separated for the estimation of hepatic enzymes alanine aminotransferase (ALT or GPT)
activities, alkaline phosphates (ALP) activities, AST, total cholesterol, Gamma-GT, Triglyceride, blood
urea nitrogen, serum creatinine, uric acid and total protein and sacrificed the all groups animals
removed liver and kidney were excised out and fixed for histopathology studies. Statistical analysis was
performed as the mean± standard deviation (SD).

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