Recent Advancement in Mucoadhesive buccal drug delivery system

Posted by Phani Raj | Posted in IJRRPAS (2018) VOL.8(1) | Posted on 17-02-2018

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Authors: Upadhyay Vivek, Monika


Mucoadhesive drug delivery system may be designed to enable extended retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome.In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrier to reach the systemic circulation.Buccal delivery involves the administration of the desired drug through the buccal mucosal membrane lining of
the oral cavity.The buccal region of the oral cavity is an attractive target for administration of the drug of choice, particularly in overcoming deficiencies associated with the eventual mode of administration.When the biological substrate is bind to a mucosal layer then this phenomenon is known as mucoadhesion. degree of mucoadhesion bonding is effected by various polymer-based properties.because of the mucosal surface usually being rich in blood supply, it increase drug bioavailability, thereby enabling rapid drug transport to the systemic circulation. moreover, in most cases, it prevent degradation by first-pass hepatic metabolism.mucoadhesive drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases.this review article aims to provide an overview of importance mucoadhesive buccal drug delivery system, polymers used in buccal drug delivery, recent advancement in mucoadhesive buccal drug delivery system, future prospects and conclusion of mucoadhesive buccal drug
delivery system.

Keyword: mucoadhesive , retention, biological substrate, administration.

Download PDF: Upadhyay Vivek et al., Int. J. Res. Rev. Pharm. Appl. Sci.,(2018) 8(1) 045-054

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