Abstract
A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Quetiapine in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 was employed on a symmetry C18 column at ambient temperature. The mobile phase consisted of Methanol:Acetonitrile:OPA 35:35:30 (v/v/v). The UV detection wavelength was at 238nm.Linearity was observed in concentration range of 10-35ppm. The retention time for Quetiapine was 7.33 min. The method was validated as per the ICH guidelines. The proposed method can be successfully applied for the estimation of Quetiapine in pharmaceutical dosage forms
AVF shortcode render error: Layout is missing (avf-layout name="Article Addons" view-id="66d98451c48e3")