Application of MBTH/Fecl3: A Reliable and Coast Effective Analytical Methodology for Routine Pharmaceutical Determination of Chlorpromazine Hydrochloride

Abstract

The present work reports a new spectrophotometric method for chlorpromazine hydrochloride
(CPZ) assay. This is based on the oxidative coupling ability of 3-Methylbenzthiazolinone-2-hydrzone
(MBTH) with the drug in presence of FeCl3 under acidic condition. The resultant water soluble colored
chromogen showed maximum absorbance at 720nm.The reaction system obeyed Beer’s law in the range
of 2-10μg/ml. The proposed method has been successfully applied for routine pharmaceutical analysis
of the sited drug.

Issue :

2011 Volume-01

Article Category :

Research Article

Article Subject :

Chemistry

Article Authors :

Vijay Raju .G, SK.Jaffar, M.Pallavi priya, S.M.Ibrahim, P.Rajakumar, E.Muralinath, M.Guru Prasad

Keywords :

Chlorpromazine hydrochloride, 3 -Methylbenzthiazolinone-2-hydrzone, Beer’s law..

Article PDF :

202-206.