Abstract
A new stability indicating HPLC method developed and validated for the dissolution analysis of Venlafaxine hydrochloride in its pharmaceutical dosage forms. In this method Kromasil C 18 column was used, mobile phase combination used was sodium acetate buffer-acetonitrilein the ratio of 75:25 with UV-detection at 227 nm. This method was validat2ed as per ICH guidelines for specificity, linearity, precision and accuracy. Forced degradation studies were performed on the bulk sample using 0.5 N HCl, 0.1 N NaOH, 33 % H2O2 and heat (50 ºC).
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