Tag: antiangeogenic

Abstract A trihydroxy anthraquinone component from Cassia fistula fruit pulp belonging toLegumenosae family was isolated from the toluene extract of fruit pulp by the process ofhot extraction and characterized as 1,3,8–trihydroxyanthraquinone (AQ) using variousspectroscopic techniques like I.R, U.V, NMR,and Mass. It is the first report of thepresence of 1,3,8 – trihydroxyanthraquinone in Cassia Fistula fruit pulp. In vitroantioxidant activity of the compound was studied by superoxide and hydroxide radicalscavenging assay. This phytoligand was also subjected to in silico molecular dockingstudies with CK2, P53 and ERK protein using iGEMDOCK software to investigate theircytotoxic activity. The in vitro cytotoxic activity of this compound was then studied tosubstantiate the data obtained from the docking studies in HT-29, DLA and A375 celllines. Its Chorio Allantoic Membrane (CAM) assay was also performed in chick embryo tofind the antiangeogenic activity [avf_view name="Article Addons" view-id="66d98451c48e3"]