Tag: Histamine

Abstract Objective: To study the In-vitro and In-vivo Anti asthmatic Activity of Clerodendrum phlomidis Linn. . (Family: Verbaneceae) in Guinea Pigs Methods: The ethanolic extract of leaves of Clerodendrum phlomidis was administered orally at the dosage levels of 100, 200, mg/kg/day and 400 mg/kg/day body weight in Guinea Pigs. The assessment of Anti asthmatic Activity activity were studied by isolated guinea pig ileum preparation, histamine induced bronchoconstriction and Histamine induced bronchoconstriction in Guinea pig has performed.. The significantly prolonged the latent period of convulsions followed by exposure to histamine aerosol at the dose of 400mg/kg, (per oral) Results: The results of the present study Isolated guinea pig ileum preparation ethanol extract of Clerodendrum phlomidis exhibited significant (***p< 0.01, <0.001) percent decreased contraction at 100mg/ml in isolated guinea pig ileum preparation. (Table: 1, Figure: 1) Histamine induced bronchoconstriction in Guinea pig. The ethanol extract of leaves of Clerodendrum phlomidis significantly prolonged the latent period of convulsions followed by exposure to histamine aerosol at the dose of 400mg/kg, (per oral) and Showed maximum protection of 59.04 % at 4th hour as compared to Chlorpheniramine maleate (Standard) 1mg/kg, (per oral) (p.o). This offered maximum protection of 65.04 % at 4th hour. (Table 2 & 3, Figure: 2&3). Conclusion: In the present investigation, it can be concluded from the result obtained that Clerodendrum phlomidis possesses significant dose-dependent anti asthmatic activity at 100,200 and 400mg/kg (per oral). [avf_view name="Article Addons" view-id="66d98451c48e3"]