Tag: Isoproterenol

Abstract The present study was designed to investigate whether Grewia umbelliferea, a natural herb, would attenuate the acute myocardialinfarction in isoproterenol (ISP)-treated rat model via maintaining cardiac function and activities of endogenous antioxidant enzymes.Heart tissue enzyme analysis in albino (Wistar) male rats, such as LPO, GSH, GPX, GST, SOD, CAT, CK-MB, MDA and biochemicalanalysis in serum plasma viz., ALT, AST, LDH, CPK were performed. The lethal doses (LD50) of the plant extract was determined bymethod of Lorke using 13 rats. In the first phase rats were divided into 3 groups of 3 rats each and were treated with the ethanol extractof the seed at doses of 10, 100 and 1000 mg/kg body weight. They were observed for 24 h for signs of toxicity. In the second phase 4rats were divided into 4 groups of 1 rat each and were also treated with the ethanolic extract at doses of 1000, 1600, 2900 and 5000mg/kg bodyweight. The median lethal dose (LD50) was calculated using the second phase. Ethanolic extract of the plant at the dose of(100& 200 mg/kg/p.o) produced significant salvages the heart from isoproterenol induced myocardial ischemic injury. The resultsindicate that plant administration causes myocardial adaptation by augmenting endogenous antioxidants and protects rat hearts fromdecline in cardiac function and oxidative stress associated with the plant induced myocardial injury, and justify its potential therapeuticvalue in the treatment of ischemic heart diseases in albino rats. [avf_view name="Article Addons" view-id="66d98451c48e3"]