Tag: Metoclopramide

Abstract A simple, specific, accurate and precise reverse phase high performance liquid chromatographicmethod was developed and validated for the estimation of Metoclopramide in tablet dosage form. AnZodiac C-18, 5μm column having 250 x 4.6mm internal diameter in isocratic mode with mobile phasecontaining Acetonitrile:1%TEA 50:50 (/v/v) was used. The flow rate was 1.0ml/min and effluents weremonitored at 250nm. The retention time for Metoclopramide was 2.565 min. The method was validatedfor linearity, accuracy, precision, specificity, limit of detection, limit of quantification and robustness.Limit of detection and limit of quantification were found to be 0.03ppm and 0.099ppm respectively andrecovery of Metoclopramide from tablet formulation was found to be 8.73%. The proposed method wassuccessfully applied for the quantitative determination of Metoclopramide in tablet formulation. [avf_view name="Article Addons" view-id="66d98451c48e3"]