Abstract A simple, selective, linear, precise and accurate RP-HPLC method was developed and validatedfor rapid assay of Quetiapine in tablet dosage form. Isocratic elution at a flow rate of 1ml min-1 wasemployed on a symmetry C18 column at ambient temperature. The mobile phase consisted ofMethanol:Acetonitrile:OPA 35:35:30 (v/v/v). The UV detection wavelength was at 238nm.Linearity wasobserved in concentration range of 10-35ppm. The retention time for Quetiapine was 7.33 min. Themethod was validated as per the ICH guidelines. The proposed method can be successfully applied forthe estimation of Quetiapine in pharmaceutical dosage forms [avf_view name="Article Addons" view-id="66d98451c48e3"]